![]() Patients with measurable disease will be evaluated for clinical benefit as determined by tumor response using RECIST v1.1. Tumor response will be evaluated using the PCWG3 criteria. Mean time to maximum Enzalutamide serum concentration (Tmax) after administration.Mean time to maximum TVB-2640 serum concentration (Tmax) after administration.Peripheral blood will be drawn at the following times: The maximum sample size for the phase I will be 30 patients and the target DLT rate is 25% or less and a maximum of 9 patients at any dose level. The dose escalation scheme will be the Bayesian optimal interval (BOIN) design with additional dose levels of 100 mg, 150mg, 200 mg, 250 mg, and 300mg daily. ![]() Participants who complete the Enzalutamide run-in period will begin oral TVB-2640 at the dose of 100 mg. All patients will receive Enzalutamide monotherapy at the approved dose of 160 mg once daily for 28 days to reach the steady state as determined by measuring Enzalutamide and des-methyl-Enzalutamide levels. This study represents the first clinical evaluation of TVB-2640 in combination with Enzalutamide. Patients with a confirmed histological or cytological diagnosis of prostate cancer (PC), evidence of metastatic PC on imaging (bone scan and/or CT/MRI scan), serum testosterone <50 ng/dl, who had progressed on androgen-depletion therapy (ADT), with documented progressive metastatic castration-resistant prostate cancer (mCRPC) based on Prostate Cancer Working Group 3 (PCWG3) criteria and no previously treatment with cytotoxic chemotherapy are eligible. This phase I, open-label, dose-escalation study is designed to evaluate the dose limiting toxicities (DLTs) and maximum-tolerated dose (MTD) of TVB-2640 plus Enzalutamide and establish the TVB-2640 dose recommended for further investigation in phase 2 (i.e., recommended phase 2 dose ). Prostatic Neoplasms, Castration-Resistant Participation in this research will last about 12 to 24 months after enrollment. By doing this study, the investigators hope to learn if combining Enzalutamide with TVB-2640 can be done safely. This research study is being done because additional effective treatments are needed for prostate cancer that has spread and is growing despite hormone suppression. Although Enzalutamide is already being used to treat men with prostate cancer, combining Enzalutamide with TVB-2640 together in patients with prostate cancer is considered experimental. "Investigational" means that the drug is still being studied and research doctors are trying to find out more about it. Phase I clinical trials test the side effects of an investigational drug or an investigational combination with another drug. The purpose of this study is to determine what effects (good and bad) Enzalutamide and TVB-2640 have in the treatment of prostate cancer whose prostate cancer has spread to other parts of their body and that has not gotten better with previous treatment. Why Should I Register and Submit Results?. ![]()
0 Comments
![]() Here, I will talk about how you do the functions stand out if you really need to deal with complex sets of data using the Navicat Data Modeler 3. Even though I’m not profound in dealing with databases, thus if I can understand it then anyone can. It is almost a few weeks now that I am using this program for the purpose of data modeling, and thus, I’m here with a review. That being said, I will talk about the Navicat Data Modeler 3. When it is all about connecting multiple tables or databases, things might get complicated pretty fast, and that’s when you need a proper data modeling tool, where you can work with the tables create connections between them in the most effortless way before you proceed with the actual database. Working with databases sometimes involves the need to create a connection between different tables within a database, or a connection with multiple databases. However, if your task is limited, just with structured data, some database management tools can really get the job done for you. Well, the time has changed, and besides structural data, we sometimes have to deal with semi-structured and unstructured data, and dealing with them is a real challenge if you want to do them with traditional database management applications. ![]() ![]() ![]() Managing data in a systematic way makes our work a lot easier, and maintaining a database is undoubtedly one of the best and proven ways to manage a lot of data seamlessly. An er diagram tool for macOS, Windows and Linux OS. A review of trail cum premium Navicat Data modeler software to design database via data modeling for dedicated database developer and/or an administrator. ![]() ![]() ![]() Missing SFX when navigating and selecting slots in the Load Game Menu are now in the game.DLC Specific: Custom difficulty no longer includes survival needs difficulty which is not present in the DLCs. ![]() Intro loading captions at the start of each character’s story no longer appear only in English.Hopscotch POI can no longer spawn under multiple assets on the sidewalks, fixing the bug where Wellies can clip through them as they hop across them.Fire and smoke no longer clip through the wall on the second floor of the House of Doctors.George's Holm Hatch" to prevent the creation of a "Last Shelter Visited" save file. Fixed the bug that caused fast travelling to the Shelter in the "Secondary St.Epilogue Cutscene: Performance issues no longer cause the final cutscene to hang and the audio to not be synchronized with the visuals.Encounter-specific Bobbies no longer create a temporary loss of functionality when bribed.Dead NPCs don’t spawn alive anymore after loading into area.Female Wellies/Wastrels and Criers no longer lack lip sync when talking to them.NPCs no longer instantly stand-up and clip through their beds when startled by noise.Fixed the bug that caused systemic NPC conversations and POI interactions to not trigger properly, not play audio or loop repeatedly.When crafting with weapons as reagents, they no longer appear as fractions.This patch addresses general gameplay issues, and a few bugs that were happening in some encounters. Fixed an issue with wording in the final credits for the Lightbearer DLC and Victoria DLC.Fixed an issue where music is missing from the credits when completing the Lightbearer DLC. ![]() ![]() ![]()
![]() Tools: the toolbox is one of the major components of Synfig where you will find all the tools you will need to manipulate objects.Here you will find the canvas surrounded by buttons on the right to lock/unlock keyframes, switch to animation mode, a little black triangle on the upper left corner called the caret, and the timeline in case you have defined a non-zero animation. ![]() Canvas: The Canvas is the grey checkered pattern in the middle where you can sketch out your animation and apply effects, layers, frames, and edits.In order to understand the tools and features, here is a quick overview of the Synfig studio when you first start using it. Application Interface Overview #Īs we have mentioned above, Synfig studio is an open source animation software that allows users to create seamless, quick processing, tweenless 2D animations. ![]() Now you must be able to access Synfig studio easily. Once downloaded, open your command line and type in the following commands: sudo apt-get update You will get an option to download the 32-bit or 64-bit image file, choose according to your system. In order to install Synfig 2D animation software on a Linux device, you can directly download the installer file from Synfig’s main homepage. If you are looking to find out more about other animation software programs then you can check out other guides and tutorials that we have made for you. Whether you’re new to the animation world or are advanced in your career, Synfig can make a nice edition to your skillset and help you develop a tight grasp on creating amazing 2D animations. This goes to show the scope of Synyfig as it can be used for both commercial and personal projects as well. Synfig has been used for animating quite a lot of popular projects including Morevna: Demo project, The Deadline by Morevna, The Polar Detective Prologue by Cyan Los and many other commercial projects. Please keep in mind that while using Synfig, your system should have: You can easily use Synfig on multiple operating systems including Windows, Mac OS, and Linux. Furthermore, the Synfig community is an active place to find not only tutorials on using the software application, but resources to help you find solutions in case you run into a roadblock. ![]() When it comes to using Synfig, it really is a light, fast processing animation software that can be a great addition to the illustrating pipeline of any artist working solo or in a small team. As an open source animation software, Synfig employs a “tweenless” animation system that not only cuts the time that it takes for an animation to process, but it also gives animators the ability to add drawing frame wise. Synfig is one of the best 2D animation software that has been designed for solo artists or small teams to manage their animation workflows and projects. How to Create a Basic Animation with Synfig?.In this guide, you will find all the information you need to get started. Creating 2D animations with Synfig is a free, seamless, and fast process. ![]() ![]() You can use it to recover nearly any type of data. It supports new and old iPhones and iOS software alike. Stellar Data Recovery for iPhone is available for both Windows and Mac. Give iMobie PhoneRescue a trial run to see how you like it! However, if you want to try the Premium version, you can do so risk-free as iMobie offers a 60-day money-back guarantee.Īll in all, PhoneRescue is an impressive Phone data recovery tool that you can use to retrieve lost data. You can try the free version of PhoneRescue to see how you like it. Both offer 24/7 customer support as well free upgrades for the duration of the license. You can get a 1-year license for 1 PC for $49.99 or a lifetime license for 1 PC for $69.99. When it comes to price, PhoneRescue is pretty affordable. This works great if you want to retrieve select pieces of data from either backup without restoring the entire thing. You can use it to recover lost data directly from your iPhone or retrieve data from your iCloud or iTunes backups. This can come in handy if you forgot your passcodes and don’t want to risk your phone being wiped from entering the wrong code too many times.īesides its repairing feature, PhoneRescue offers great data recovery options. In addition to repairing it, PhoneRescue can also remove your iPhone’s Screen Time passcode or its Lock Screen Passcode. This also works if your iPhone is in Recovery/DFU Mode or frozen. In the event your iPhone, or iPad crashes, you can use PhoneRescue to fix it. ![]() Most notably is its iOS system repair feature. IMobie’s dedication to providing quality software to iOS users has allowed them to develop an exceptional iPhone data recovery software, iMobie PhoneRescue.Ī comprehensive and impressive iPhone recovery software, the iMobie PhoneRescue offers a host of exciting features. It initially started focusing on data recovery and content management for iOS and Mac devices, but it has since grown to cover Android devices as well. Fone, Free Android Data Recovery, and Free Data Recovery.Started in 2011, iMobie is a software company that focuses on data recovery for iOS and Android devices. In case you want to check out a few alternatives, you should explore apps like iCareFone, Wondershare Dr. Its recovery process is a little slow and may crash when you try to restore a large file. It features various functions in a clean interface. UltData is one of the best iOS data recovery tools in the market. Are there any UltData - iPhone Data Recovery alternatives? The company also offers monthly and yearly subscription options. If you find the app quite useful, you can purchase the full version or opt for a lifetime plan. During this time, you can easily explore all the features and use them to restore data. Tenorshare’s UltData - iPhone Data Recovery download is available for free, but only for a limited period. According to the company, the software can recover up to 35 data types without losing essential data. Tenorshare, the developer of UltData, claims that their application can recover all lost or deleted iPhone data. Furthermore, when using any of the recovery tools, you can rest knowing that none of them would lead to any data loss. These include problems like stuck screen, recovery loop, and black screen, among others. ![]() On top of this, the software lets you fix more than 50 iOS issues. It also lets you preview encrypted iTunes files and perform a selective backup. With it, you can create a backup, transfer files, recover data, and restore messages, contacts, call logs, WhatsApp texts, voice notes, photographs, documents, updates, and more. One of the best parts about downloading the UltData - iPhone Data Recovery application is that it lets you restore files from local folders, as well as from your iTunes and iCloud account. What are the features of UltData - iPhone Data Recovery? At the moment, it offers a free trial period that lets you explore the app’s layout and features before committing. Designed for Windows, the app works to recover data from iPhones, iPads, iPods, and other Apple devices. Once you complete the UltData download, you get access to a clean interface that features various applications and tools to help you restore essential files.Īdditionally, the app lets you create a backup, restore data, solve iOS issues, and optimize your iOS device. Developed by Tenoshare, a company known for creating utility software, this application can come in handy in emergencies. It’s a simple data recovery tool that can restore lost or deleted files from your iOS device. In such a situation, an app like the free UltData - iPhone Data Recovery download can help. Now imagine if you end up with a non-responsive phone that you can’t switch on. This data includes contacts, applications, notes, images, videos, audio files, and more. ![]() Most users tend to keep all their essential data on their devices. Nowadays, smartphones have become an extension of our being. ![]() ![]() With its larger 3,430mAh battery, the XL model can easily last a full day of heavy use without needing to be recharged. The Pixel 3 XL has the edge over the standard Pixel 3.Pros:Īs anyone who has ever used a smartphone can attest, battery life is one of the most important features of any handset. The followings are the pros and cons of Pixel 3XL. With these options, you can create a unique and stylish home screen that matches your personality. The app provides various options for customizing the grid, including size, color, and opacity. If you’re unsatisfied with the results, you can always go back and adjust the settings or try a different background. You can then tap Done to apply the background to your home screen.Tap App grid and choose the size of your grid.To do this, go to Settings and select Wallpapers.Once you have installed the Pixel 3XL Grid 2 Background app, you can choose the grid size that you want to use. The app will then apply the background to your home screen. From here, you can choose the grid size and tap Done. To use the app, touch and hold a space on your home screen, then tap Wallpaper & style.Īt the bottom of the screen, tap App grid. ![]() Grid 2 is a free app that allows you to create a grid-based background on your Android device. How To Install Pixel 3XL Grid 2 Background On Your Android Device? Overall, the Pixel 3XL’s camera is one of the best on any smartphone today. The phone also has an all-new “night sight” mode that allows you to take incredible low-light photos without a flash. It allows for optical zoom and improved low-light performance. The phone includes two cameras on the back, one of which is a telephoto lens. One of the most notable features of the Pixel 3XL is its camera. It features a large 6.3-inch display, a Qualcomm Snapdragon 845 processor, and a 12.2-megapixel rear camera. The Pixel 3XL is a high-end Android smartphone from Google that was released in October 2018.
![]() You can access features such as status reporting, set and unset, control of groups, outputs and log details. The upgraded product allows users to access the system remotely through their own broadband connection by download of the ‘Galaxy Flex Range Mobile App’ from an application store.Īccessing Galaxy Flex via its mobile app allows remote control of the system at the touch of a button. The prevalence of smartphones and tablets means that mobile applications are becoming ever more popular. And a new compact housing according to the company is for systems that do not require several extra add-ons to the basic panel and where space is limited. The new firmware provides a set-up wizard, to simplify setting up alarm signalling to a monitoring station, with or without a back-up signalling path over telephone lines, broadband or wireless GSM/GPRS links. This feature saves installers time on the job, the makers add. It provides a silent mode, removing audible tones during arming and so allowing users to set the alarm without disturbing others. ![]() This feature enables users to arm only the sensors needed to protect the house perimeter or isolated areas of the house. The manufacturers adds that installers can fit the product without the need to learn how to operate a new system.Ī new ‘night set’ mode allows home owners to create separate night-time security set-up. The makers say that the product can be used by installers as a standard piece of equipment, whether it is being integrated into a commercial or residential building. The product, hybrid wired and wireless, is aimed at home owners and small to medium size businesses. Let's hope the NFL doesn't screw it up.Honeywell has upgraded Galaxy Flex, the intruder and access control product, with a ‘night set’ mode, a new compact housing design and a Galaxy Range Mobile App for remote access. That's a fairly decent slate the NFL's schedule makers put together and gifted us all. These are the games currently slated for Thursday nights in Weeks 13 through 17: So you've got a lot of fans - a huge majority of the fans that are out there - that this is good for them." But only 7% of our fans have ever been inside a stadium. "Every owner in that room lives and breathes sensitivity to those fans. ![]() ![]() "Very, very important point," Cowboys owner Jerry Jones said Monday when the inconvenience to the fans was mentioned. I'm told the room was fairly evenly split on the resolution before Giants co-owner John Mara stood up and called the idea "abusive."īut the determination the league and the owners have made is that, all of those people above who are impacted across those teams and cities equal a number that is far less than the number of people who will be watching on a screen somewhere. Then, the league had to give teams 15 days' notice instead of 28. The league badly wanted this to pass during the annual meetings in March in Arizona. And the league makes the tacit admission that it could be a bad idea by noting this is a "one-season trial of modified scheduling policies for flexible scheduling in connection with the Thursday Night Football package." It's a heavy set of conditions that set a high bar for this ever coming to fruition. The games are limited only to Weeks 13-17, the decision must be made no later than 28 days in advance of the game, there's a maximum of two Thursday night games that can be flexed out of the five options and, of course, the game has to warrant being flexed out of. On Monday, 24 owners voted in favor of a scheduling mechanism by which the league will be able to flex into (or out of) "Thursday Night Football'' games. Let's hope the league never has to use it. The NFL finally forced Thursday night flex scheduling into its broadcast window. ![]() ![]() ![]() That’s not good for freedom of choice and openness at all. That means you can’t video call a Whatsapp user from Skype or Facetime or anything else other than Whatsapp. all use different types of internet video calling methods and none of them are interoperable with each other. Most apps like Facebook Messenger, Instagram, Whatsapp, Viber, Skype, Telegram, Signal, Facetime, etc. ![]() Some video conferencing apps and services use the standards compliant Session Initiation Protocol (SIP) and Extensible Messaging and Presence Protocol (XMPP), but most do not, or if they do, they’ll neglect to implement the intoperability aspects so that you’ll be stuck in their silo and have to peer pressure people into using those often invasive apps. It can be either text, voice, or video-based chat that team members can use to get in touch with each other to discuss or resolve any ongoing issues.Instead, today we have dozens (maybe hundreds) of different apps designed to do video & voice over the internet protocol (VOIP). Live Chat Live chat is a medium that allows the employees to interact with website visitors or with each other in real-time.Polls (Voting) Helps to discover critical data by asking the participants questions concerning the webinar.It is the distribution of data or resources in a network, either privately or publicly, with varying levels of sharing privileges. File Sharing The act of sharing or providing access to digital information or resources, such as documents, multimedia (audio/video), graphics, computer programs, photographs, or e-books, is known as file sharing.These tools can also be used on various formats such as a whiteboard or PowerPoint presentation, to annotate the selected content. Annotation and Markup Tools An annotation and markup tool is a text or drawing tool that helps you add information to text, an image, a database, or any other piece of content.Virtual Whiteboard Interactive whiteboard to teach, explain, sketch and for online presentation.Live Preview Presents a live preview of what viewers see in real-time.Switch Presenter Allows presenter to handover presenter access to another user in a meeting. ![]()
![]() We’ve included a fair number of drinks, but if you can’t find the exact drink you consumed there may be something of similar alcoholic content (ABV). The number of units in a drink is based on. Simply tot up the drinks you consumed the night before - or better still, use the calculator smartphone app to keep track of what you’re drinking while you’re out - and the calculator will store them and give you a rough calculation of when you will be safe to drive. Registered Office: Unit 5, Blantyre Street, Manchester M15 4JJ. Alcohol units were first introduced in the UK in 1987 to help people understand how much they were drinking. This is when we suggest you will be 'safe to drive'. The 'hours before driving' calculation is not based on any drink drive limit - it is the length of time when the alcohol in the drinks you've consumed is likely to have passed through your body. Some people say this is over-cautious, but we’d rather be safe than sorry. The Maths The Maths Work out your units for yourself with this simple formula: Remember: 1litre 100cl 1000ml Strength (ABV) x Volume (ml) 1000 No. The calculator bases its calculation from the time you stop, not when you start drinking. The recommended weekly levels of alcohol consumption for adults are: Men up to 21 units and women up to 14 units per week. It then rounds up the calculation to the nearest half hour. The calculator allows one hour for each unit of alcohol, plus an additional hour for the first drink to allow for the alcohol to enter the bloodstream. And it can help you calculate when to stop drinking alcohol if you have to drive the following morning.Ī reminder: there are strict drink driving penalties if you are caught over the limit. The calculator allows one hour for each unit of alcohol, plus an additional hour for the first drink to allow for the alcohol to enter the bloodstream. What it will do is enable you to calculate roughly when it will be safe for you to drive the morning after drinking alcohol. If you are drinking any amount of alcohol on a night out - even one drink - you should leave the car at home and make alternative arrangements.Īnd the calculator won’t help you if you are arrested for drink driving. Let’s make one thing absolutely clear at the outset - this calculator is not intended to help you work out how much you can drink on a night out before driving home. The purpose of this calculator is to find how many units of alcohol exist in a given quantity of liquid when its AbV ( alcohol by volume) is known. ![]() |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |